Mixing analysis for successful scale-up of Crystallization processes

Crystallization is a unit operation which defines quality of a product of a chemical reaction or purification
process which is isolated as crystalline solid. In case of final product, a number of quality parameters such
as particle size distribution (PSD), polymorphic form, residual solvent and residual impurities, flowability
etc are required to be achieved consistently batch to batch. In case of intermediates, filtration and drying
time apart form required quality parameters are important which can affect the batch cycle time and
hence throughput upon scale-up.
Mixing plays important role in scale-up of crystallization processes. Improper mixing can cause oiling out,
agglomeration, breakage and more importantly an unstable Metastable Zone Width (MZW), which
indirectly affects nucleation and growth kinetics.
Reactive and antisolvent crystallization process are typically mixing sensitive and need fast dispersion of
the reagent/antisolvent being added to avoid formation of local supersaturation zones leading to wide
particle size distribution. In such processes, selection of agitator type, speed, dosing location etc. become
critical scale-up decisions to replicate lab scale parameters at the manufacturing scale. In this webinar, we
will present case studies highlighting how detailed mixing analysis using MixIT helps to select right
combination of reactor hardware and operating conditions to get better scale-up for crystallization
processes.

Event Date: 17 April 2025

Event Time: 8.30 PM IST | 10 AM EST | 3 PM GMT

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