Mixing analysis for successful scale-up of Crystallization processes

Crystallization is a unit operation that defines the quality of a product of a chemical reaction or purification process which is isolated as a crystalline solid. In the case of the final product, a number of quality parameters such as particle size distribution (PSD), polymorphic form, residual solvent and residual impurities, flowability, etc. are required to be achieved consistently batch to batch. In the case of intermediates, filtration and drying time apart from required quality parameters are important which can affect the batch cycle time and hence throughput upon scale-up. 

Mixing plays an important role in the scale-up of crystallization processes. Improper mixing can cause oiling out, agglomeration, breakage, and more importantly, an unstable Metastable Zone Width (MZW), which indirectly affects nucleation and growth kinetics. 

Reactive and antisolvent crystallization processes are typically mixing sensitive and need fast dispersion of the reagent/antisolvent being added to avoid the formation of local supersaturation zones leading to wide particle size distribution. In such processes, selection of agitator type, speed, dosing location, etc. become critical scale-up decisions to replicate lab scale parameters at the manufacturing scale.

In this webinar, Our Mixing Science Experts will present case studies highlighting how detailed mixing analysis using MixIT helps to select the right combination of reactor hardware and operating conditions to get better scale-up for crystallization processes.  

Webinar Agenda: 

• Mixing Analysis: To enhance product yield and batch cycle times by 30% 
• Achieve consistent batch-to-batch product quality 
• Case Studies: Scale-up for crystallization processes 
• Q&A  

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