Abbvie – a BioPharmaceutical R&D Company performs an insightful research using Tridiagonal Solutions Flagship product MixIT on the “Investigation of Variable Impurity Profile from a Mitsunobu Reaction Using Insights from Kinetic Modeling, Multi-Phase Interactions, and Computational Fluid Dynamics”
San Antonio, TX, USA, April 11, 2016
Samrat Mukherjee, Shailendra Bordawekar, and Nandkishor Nere from Process Research and Development, Abbvie Inc; USA published an article on “Investigation of Variable Impurity Profile from a Mitsunobu Reaction Using Insights from Kinetic Modeling, Multi-Phase Interactions, and Computational Fluid Dynamics” in I&EC Research Journal. This investigative article showcases how Tridiagonal Solutions – MixIT software solution performed Computational fluid dynamics simulation of the mixing patterns and a series of proof-of-concept experiments to establish the influence of mixing intensity and cocrystal formation on the level of impurity formed. A drug substance intermediate synthesis involving a Mitsunobu coupling reaction using triphenylphosphine and diisopropyl azodicarboxylate was investigated to understand the variable levels of an impurity.
MixIT played a crucial role in identifying well characterized vessels with good mixing capability to control the nucleation of TPPO – H2DIAD cocrystal formation. The CFD Simulations for 1L reactor with and without baffles provided significant insights into the local mixing pattern which significantly influences the nucleation characteristics. To read the complete article, please click here
AbbVie Inc. (AbbVie), incorporated on April 10, 2012, is a research-based biopharmaceutical company. The Company is engaged in the discovery, development, manufacture and sale of a range of pharmaceutical products. With ~29,000 employees and medicines in over 175 countries, AbbVie is uniting the best of pharma and the boldness of biotech, to innovate end-to-end approaches that make a real difference in people’s lives. Learn more about Abbvie @ http://abbvie.com
About Tridiagonal Solutions
Tridiagonal solutions is a process performance enhancement service provider. Tridiagonal’s mixing experts team helps global companies simplify and automate their mixing processes, thereby enabling them to accelerate process scale-ups and reduce uncertainties during tech-transfers. Tridiagonal possesses more than 12+ years of industry experience and working with Multinational & Multisectoral fortune 100 Clients. Learn more about Tridiagonal Solutions @ https://tridiagonal.com/
Tridiagonal Solutions one of the flagship product is MixIT – The enterprise Mixing Analysis Tool. MixIT is the next generation collaborative mixing analysis and scale-up tool designed to facilitate comprehensive stirred tank analysis using lab and plant data, empirical correlations and advanced 3D CFD models. It combines knowledge management tools and mixing science in a unified environment deployable enterprise-wide.